CallistoPronunciation: /kəˈlɪstəʊ/Definition of Callisto 1 Greek Mythology a nymph who was changed into a bear by Zeus. See also Ursa Major. 2 Astronomy one of the Galilean moons of Jupiter, the eighth-closest satellite to the planet, icy with a dark, cratered surface (diameter 4,800 km). Callisto in other Oxford dictionaries Definition of Callisto in the US English dictionary