COX-2 inhibitor Syllabification: (COX-2 in·hib·i·tor)Entry from US DictionaryDefinition of COX-2 inhibitor noun a painkiller that works by inhibiting the enzyme cyclooxygenase-2 (COX-2), which triggers the release of prostaglandins. COX-2 inhibitor in other Oxford dictionaries Definition of COX-2 inhibitor in the US English dictionary