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1 (Dame) (in the UK) the title given to a woman with the rank of Knight Commander or holder of the Grand Cross in the Orders of Chivalry: Dame Vera Lynn
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2 archaic or humorous an elderly or mature woman: a matronly dame presided at the table
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North American informal a woman: a rich dame who took her husband to the cleaners
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(also pantomime dame) British a comic middle-aged female character in modern pantomime, usually played by a man.