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1an act of cleaning a place: an environmental clean-up
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an act of putting an end to immorality or crime: a clean-up of the more open violence had begun
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2 [usually as modifier] Baseball the fourth position in a team’s batting order, usually reserved for a strong batter whose hits are likely to enable any runner who is on base to score: L.A.’s clean-up hitter Clarence Maddern smacked a fastball over the left-field fence