wormhole Syllabification: (worm·hole)Pronunciation: /ˈwərmˌhōl/Translate wormhole | into Italian Definition of wormhole noun a hole made by a burrowing insect larva or worm in wood, fruit, books, or other materials. Physics a hypothetical connection between widely separated regions of space-time. wormhole in other Oxford dictionaries Definition of wormhole in the British & World English dictionary