urokinase Syllabification: (u·ro·ki·nase)Pronunciation: /ˌyo͝orōˈkīˌnās, -ˌnāz/Definition of urokinase noun Biochemistry an enzyme produced in the kidneys that promotes the conversion of plasminogen to plasmin and can be used to dissolve blood clots. urokinase in other Oxford dictionaries Definition of urokinase in the British & World English dictionary