trophoblast Syllabification: (troph·o·blast)Pronunciation: /ˈträfəˌblast, ˈtrō-/Definition of trophoblast noun Embryology a layer of tissue on the outside of a mammalian blastula, supplying the embryo with nourishment and later forming the major part of the placenta. Derivatives trophoblasticPronunciation: /ˌträfəˈblastik/ adjective trophoblast in other Oxford dictionaries Definition of trophoblast in the British & World English dictionary