transactivation Syllabification: (trans·ac·ti·va·tion)Pronunciation: /tranˌsaktəˈvāSHən, -ˌzakt-/Definition of transactivation noun Biochemistry activation of a gene at one locus by the presence of a particular gene at another locus, typically following infection by a virus. transactivation in other Oxford dictionaries Definition of transactivation in the British & World English dictionary