toluene Syllabification: (tol·u·ene)Pronunciation: /ˈtälyo͞oˌēn/Definition of toluene noun Chemistry a colorless liquid hydrocarbon present in coal tar and petroleum and used as a solvent and in organic synthesis. Alternative name: methylbenzene; chemical formula: C6H5CH3 Origin: late 19th century: from tolu + -enetoluene in other Oxford dictionaries Definition of toluene in the British & World English dictionary