tamponade Syllabification: (tam·pon·ade)Pronunciation: /ˌtampəˈnād/Definition of tamponade noun Medicine 1 (in full cardiac tamponade) compression of the heart by an accumulation of fluid in the pericardial sac. 2the surgical use of a plug of absorbent material. tamponade in other Oxford dictionaries Definition of tamponade in the British & World English dictionary