synostosis Syllabification: (syn·os·to·sis)Pronunciation: /ˌsinäˈstōsis/Definition of synostosis noun (plural synostoses /-sēz/) Physiology & Medicine the union or fusion of adjacent bones by the growth of bony substance, either as a normal process during growth or as the result of ankylosis. Origin: mid 19th century: from syn- 'together' + Greek osteon 'bone' + -osissynostosis in other Oxford dictionaries Definition of synostosis in the British & World English dictionary