syncytium Syllabification: (syn·cy·tium)Pronunciation: /sinˈsiSHəm/Definition of syncytium noun (plural syncytia /-ˈsiSHə/) Biology a single cell or cytoplasmic mass containing several nuclei, formed by fusion of cells or by division of nuclei. Embryology syncytium forming the outermost layer of the trophoblast. Derivatives syncytialPronunciation: /-SHəl/ adjective Origin: late 19th century: from syn- 'together' + -cyte 'cell' + -iumsyncytium in other Oxford dictionaries Definition of syncytium in the British & World English dictionary