spondylosis Syllabification: (spon·dy·lo·sis)Pronunciation: /ˌspändəˈlōsis/Definition of spondylosis noun Medicine a painful condition of the spine resulting from the degeneration of the intervertebral disks. Origin: early 20th century: from Greek spondulos 'vertebra' + -osisspondylosis in other Oxford dictionaries Definition of spondylosis in the British & World English dictionary