splenium Syllabification: (sple·ni·um)Pronunciation: /ˈsplēnēəm/Definition of splenium noun Anatomy the thick posterior part of the corpus callosum of the brain. Derivatives splenialPronunciation: /ˈsplēnēəl/ adjective Origin: mid 19th century: from Latinsplenium in other Oxford dictionaries Definition of splenium in the British & World English dictionary