sphingolipid Syllabification: (sphin·go·lip·id)Pronunciation: /ˌsfiNGgōˈlipid/Definition of sphingolipid noun Biochemistry any of a class of compounds that are fatty acid derivatives of sphingosine and occur chiefly in the cell membranes of the brain and nervous tissue. sphingolipid in other Oxford dictionaries Definition of sphingolipid in the British & World English dictionary