spermidine Syllabification: (sper·mi·dine)Pronunciation: /ˈspərməˌdēn/Definition of spermidine noun Biochemistry a colorless compound with a similar distribution and effect to spermine. A polyamine; chemical formula: H2N(CH2)3NH(CH2)4NH2 Origin: 1920s: from sperm + -ide + -ine4spermidine in other Oxford dictionaries Definition of spermidine in the British & World English dictionary