spasmolytic Syllabification: (spas·mo·lyt·ic)Pronunciation: /ˌspazməˈlitik/ MedicineDefinition of spasmolytic adjective (of a drug or treatment) able to relieve spasm of smooth muscle. noun a drug that relieves spasm of smooth muscle. spasmolytic in other Oxford dictionaries Definition of spasmolytic in the British & World English dictionary