sotol Syllabification: (so·tol)Pronunciation: /ˈsōˌtōl/Definition of sotol noun a North American desert plant of the agave family, with spiny-edged leaves and small white flowers. Genus Dasylirion, family Agavaceae: several species, including smooth-leaf sotol (D. leiophyllum) an alcoholic drink made from the sap of the sotol. Origin: late 19th century: via American Spanish from Nahuatl tzotollisotol in other Oxford dictionaries Definition of sotol in the British & World English dictionary