skepticism Syllabification: (skep·ti·cism)Pronunciation: /ˈskeptəˌsizəm/ (British scepticism)Translate skepticism | into French | into Italian | into Spanish Definition of skepticism noun 1a skeptical attitude; doubt as to the truth of something:these claims were treated with skepticism 2 Philosophy the theory that certain knowledge is impossible. skepticism in other Oxford dictionaries Definition of skepticism in the British & World English dictionary