secretin Syllabification: (se·cre·tin)Pronunciation: /siˈkrētn/Definition of secretin noun Biochemistry a hormone released into the bloodstream by the duodenum (especially in response to acidity) to stimulate secretion by the liver and pancreas. Origin: early 20th century: from secretion + -in1secretin in other Oxford dictionaries Definition of secretin in the British & World English dictionary