psychotomimetic Syllabification: (psy·chot·o·mi·met·ic)Pronunciation: /ˌsīˌkätōməˈmetik/Definition of psychotomimetic adjective relating to or denoting drugs that are capable of producing an effect on the mind similar to a psychotic state. noun a psychotomimetic drug. psychotomimetic in other Oxford dictionaries Definition of psychotomimetic in the British & World English dictionary