prurigo Syllabification: (pru·ri·go)Pronunciation: /pro͝oˈrīgō, -ˈrēgō/Definition of prurigo noun Medicine a chronic skin disease causing severe itching. Derivatives pruriginousPronunciation: /pro͝orˈijənəs/ adjective Origin: mid 17th century: from Latin, from prurire 'to itch'prurigo in other Oxford dictionaries Definition of prurigo in the British & World English dictionary