proteolysis Syllabification: (pro·te·ol·y·sis)Pronunciation: /ˌprōtēˈäləsəs/Definition of proteolysis noun Biochemistry the breakdown of proteins or peptides into amino acids by the action of enzymes. Derivatives proteolyticPronunciation: /-əˈlitik/ adjective proteolyticallyPronunciation: /-əˈlitik(ə)lē/ adverb Origin: late 19th century: modern Latin, from protein + -lysisproteolysis in other Oxford dictionaries Definition of proteolysis in the British & World English dictionary