prostaglandin Syllabification: (pros·ta·glan·din)Pronunciation: /ˌprästəˈglandin/Definition of prostaglandin noun Biochemistry any of a group of cyclic fatty acid compounds with varying hormonelike effects, notably the promotion of uterine contractions. Origin: 1930s: from prostate + gland1 + -in1prostaglandin in other Oxford dictionaries Definition of prostaglandin in the British & World English dictionary