prophage Syllabification: (pro·phage)Pronunciation: /ˈprōˌfāj/Definition of prophage noun Microbiology the genetic material of a bacteriophage, incorporated into the genome of a bacterium and able to produce phages if specifically activated. Origin: 1950s: from pro-2 'before' + phageprophage in other Oxford dictionaries Definition of prophage in the British & World English dictionary