pronucleus Syllabification: (pro·nu·cle·us)Pronunciation: /prōˈn(y)o͞oklēəs/Definition of pronucleus noun (plural pronuclei /-klēˌī/) Biology either of a pair of gametic nuclei, in the stage following meiosis but before their fusion leads to the formation of the nucleus of the zygote. Derivatives pronuclearPronunciation: /-klēər/ adjective pronucleus in other Oxford dictionaries Definition of pronucleus in the British & World English dictionary