polyposis Syllabification: (pol·yp·o·sis)Pronunciation: /ˌpäliˈpōsəs/Definition of polyposis noun Medicine a condition characterized by the presence of numerous internal polyps, especially a hereditary disease ( familial adenomatous polyposis) that affects the colon and in which the polyps may become malignant. polyposis in other Oxford dictionaries Definition of polyposis in the British & World English dictionary