polygenic Syllabification: (pol·y·gen·ic)Pronunciation: /ˌpäliˈjenik/Definition of polygenic adjective Genetics of, relating to, or determined by polygenes. Derivatives polygenicallyPronunciation: /-ik(ə)lē/ adverb Origin: 1940s: from Greek polugenēs 'of many kinds' + -icpolygenic in other Oxford dictionaries Definition of polygenic in the British & World English dictionary