polygenesis Syllabification: (pol·y·gen·e·sis)Pronunciation: /ˌpäliˈjenəsəs/Definition of polygenesis noun origination from several independent sources, in particular. Biology the hypothetical origination of a race or species from a number of independent stocks. Compare with polygeny. the hypothetical origination of language or of a surname from a number of independent sources in different places at different times. polygenesis in other Oxford dictionaries Definition of polygenesis in the British & World English dictionary