polyethylene glycol Syllabification: (pol·y·eth·yl·ene gly·col)Definition of polyethylene glycol noun a synthetic resin made by polymerizing ethylene glycol, in particular any of a series of water-soluble oligomers and polymers used chiefly as solvents or waxes. polyethylene glycol in other Oxford dictionaries Definition of polyethylene glycol in the British & World English dictionary