papain Syllabification: (pa·pa·in)Pronunciation: /pəˈpā-in, -ˈpī-/Definition of papain noun a protein-digesting enzyme obtained from unripe papaya fruit, used to tenderize meat and as a food supplement to aid digestion. Origin: late 19th century: from papaya + -in1papain in other Oxford dictionaries Definition of papain in the British & World English dictionary