pacemaker Syllabification: (pace·mak·er)Pronunciation: /ˈpāsˌmākər/Translate pacemaker | into French | into German | into Italian | into Spanish Definition of pacemaker noun 1an artificial device for stimulating the heart muscle and regulating its contractions. the part of the heart muscle (the sinoatrial node) that normally performs this role. the part of an organ or of the body that controls any other rhythmic physiological activity. 2another term for pacesetter.Derivatives pacemakingPronunciation: /-ˌmākiNG/ adjective & noun pacemaker in other Oxford dictionaries Definition of pacemaker in the British & World English dictionary