oxacillin Syllabification: (ox·a·cil·lin)Pronunciation: /ˌäksəˈsilin/Definition of oxacillin noun Medicine an antibiotic drug made by chemical modification of penicillin and used to treat bacterial infections. Origin: 1960s: blend of oxazole and penicillinoxacillin in other Oxford dictionaries Definition of oxacillin in the British & World English dictionary