osteolysis Syllabification: (os·te·ol·y·sis)Pronunciation: /ˌästēˈäləsis/Definition of osteolysis noun Medicine the pathological destruction or disappearance of bone tissue. Derivatives osteolyticPronunciation: /-əˈlitik/ adjective osteolysis in other Oxford dictionaries Definition of osteolysis in the British & World English dictionary