orbitofrontal cortex Syllabification: (or·bit·o·fron·tal cor·tex)Pronunciation: /ˌôrbitəˌfrəntlˈkôrteks/Definition of orbitofrontal cortex noun Anatomy the area of the cerebral cortex located at the base of the frontal lobes above the orbits (or eye sockets), involved especially in social and emotional behavior. orbitofrontal cortex in other Oxford dictionaries Definition of orbitofrontal cortex in the British & World English dictionary