neoplasm Syllabification: (ne·o·plasm)Pronunciation: /ˈnēəˌplazəm/Definition of neoplasm noun a new and abnormal growth of tissue in some part of the body, especially as a characteristic of cancer. Origin: mid 19th century: from neo- 'new' + Greek plasma 'formation' (see plasma)neoplasm in other Oxford dictionaries Definition of neoplasm in the British & World English dictionary