nagana Syllabification: (na·ga·na)Pronunciation: /nəˈgänə/Definition of nagana noun a disease of cattle, antelope, and other livestock in southern Africa, characterized by fever, lethargy, and edema, and caused by trypanosome parasites transmitted by the tsetse fly. Origin: late 19th century: from Zulu nakanenagana in other Oxford dictionaries Definition of nagana in the British & World English dictionary