muscadine Syllabification: (mus·ca·dine)Pronunciation: /ˈməskəˌdīn/Definition of muscadine noun any of a group of species and varieties of wine grape native to Mexico and the southeastern US, typically having thick skins and a musky flavor. Genus Vitis (section Muscadinia): several species, in particular V. rotundifolia Origin:probably an alteration of muscatelmuscadine in other Oxford dictionaries Definition of muscadine in the British & World English dictionary