monosaccharide Syllabification: (mon·o·sac·cha·ride)Pronunciation: /ˌmänəˈsakəˌrīd/Definition of monosaccharide noun Chemistry any of the class of sugars (e.g., glucose) that cannot be hydrolyzed to give a simpler sugar. monosaccharide in other Oxford dictionaries Definition of monosaccharide in the British & World English dictionary