mononucleosis Syllabification: (mon·o·nu·cle·o·sis)Pronunciation: /ˌmänəˌn(y)o͞oklēˈōsəs/Definition of mononucleosis noun Medicine an abnormally high proportion of monocytes in the blood. short for infectious mononucleosis.Also called mono.mononucleosis in other Oxford dictionaries Definition of mononucleosis in the British & World English dictionary