mesocyclone Syllabification: (mes·o·cy·clone)Pronunciation: /ˌmezəˈsīklōn, ˌmesə-, ˌmēzə-, ˌmēsə-/Definition of mesocyclone noun Meteorology a cyclonic air mass associated with a supercell; its presence is a condition for a tornado warning. Origin: late 20th century