megaloblast Syllabification: (meg·a·lo·blast)Pronunciation: /ˈmegələˌblast/Definition of megaloblast noun Medicine a large, abnormally developed red blood cell typical of certain forms of anemia, associated with a deficiency of folic acid or of vitamin B12. Derivatives megaloblasticPronunciation: /ˌmegəlōˈblastik/ adjective megaloblast in other Oxford dictionaries Definition of megaloblast in the British & World English dictionary