macrostructure Syllabification: (mac·ro·struc·ture)Pronunciation: /ˈmakrōˌstrəkCHər/Definition of macrostructure noun the large-scale or overall structure of something, e.g., an organism, a mechanical construction, or a written text. Derivatives macrostructuralPronunciation: /ˌmakrōˈstrəkCHərəl/ adjective macrostructure in other Oxford dictionaries Definition of macrostructure in the British & World English dictionary