macromolecule Syllabification: (mac·ro·mol·e·cule)Pronunciation: /ˌmakrōˈmäləˌkyo͞ol/Definition of macromolecule noun Chemistry a molecule containing a very large number of atoms, such as a protein, nucleic acid, or synthetic polymer. Derivatives macromolecularPronunciation: /-məˈlekyələr/ adjective macromolecule in other Oxford dictionaries Definition of macromolecule in the British & World English dictionary