macrogamete Syllabification: (mac·ro·gam·ete)Pronunciation: /ˌmakrōgəˈmēt, -ˈgamˌēt/Definition of macrogamete noun Biology (especially in protozoans) the larger of a pair of conjugating gametes, usually regarded as female. macrogamete in other Oxford dictionaries Definition of macrogamete in the British & World English dictionary