lysozyme Syllabification: (ly·so·zyme)Pronunciation: /ˈlīsəˌzīm/Definition of lysozyme noun Biochemistry an enzyme that catalyzes the destruction of the cell walls of certain bacteria, occurring notably in tears and egg white. Origin: early 20th century: from lysis + a shortened form of enzymelysozyme in other Oxford dictionaries Definition of lysozyme in the British & World English dictionary