lysine Syllabification: (ly·sine)Pronunciation: /ˈlīˌsēn/Definition of lysine noun Biochemistry a basic amino acid that is a constituent of most proteins. It is an essential nutrient in the diet of vertebrates. Chemical formula: NH2(CH2)4CH(NH2)COOH Origin: late 19th century: from German Lysin, based on lysislysine in other Oxford dictionaries Definition of lysine in the British & World English dictionary