lyophilize Syllabification: (ly·oph·i·lize)Pronunciation: /līˈäfəˌlīz/Definition of lyophilize verb [with object] technical freeze-dry (a substance). Derivatives lyophilizationPronunciation: /-ˌäfələˈzāshən, -ˌlīˈzā-/ noun lyophilize in other Oxford dictionaries Definition of lyophilize in the British & World English dictionary