lidocaine Syllabification: (li·do·caine)Pronunciation: /ˈlīdəˌkān/Definition of lidocaine noun Medicine a synthetic compound used as a local anesthetic, e.g., for dental surgery, and in treating abnormal heart rhythms. An aromatic amide; chemical formula: C14H22N2O Origin: 1940s: from (acetani)lid(e) + -caine (from cocaine)lidocaine in other Oxford dictionaries Definition of lidocaine in the British & World English dictionary