isoprene Syllabification: (i·so·prene)Pronunciation: /ˈīsəˌprēn/Definition of isoprene noun Chemistry a volatile liquid hydrocarbon obtained from petroleum, whose molecule forms the basic structural unit of natural and synthetic rubbers. Chemical formula: CH2C(CH3)CHCH2 Origin: mid 19th century: apparently from iso- 'equal' + pr(opyl)eneisoprene in other Oxford dictionaries Definition of isoprene in the British & World English dictionary